Review of immunoglobulin G4-related salivary diseases and a case of Küttner’s tumor

Kerimcan Çakıcı; Ozan Gökdoğan; Yelda Dere; Harun Üçüncü; Sabri Köseoğlu; Erdoğan Özgür

doi:10.5606/kbbu.2019.82788

Kerimcan Çakıcı¹, Ozan Gökdoğan¹, Yelda Dere², Harun Üçüncü¹, Sabri Köseoğlu¹, Erdoğan Özgür¹

¹Muğla Sıtkı Koçman Üniversitesi, Kulak Burun Boğaz Hastalıkları Anabilim Dalı, Muğla, Türkiye
²Muğla Sıtkı Koçman Üniversitesi Tıp Fakültesi, Tıbbi Patoloji Anabilim Dalı, Muğla, Türkiye

Keywords: Immunoglobulin G4-related disease, Küttner’s tumor, sialadenitis.

Abstract

Salivary glands can be affected by autoimmune diseases. Although Sjögren syndrome is the most common form of autoimmune salivary gland diseases, many other diseases may affect the salivary glands mainly through immunoglobulin G4 (IgG4)-related reactions. While Sjögren's syndrome affects the exocrine gland duct, IgG4-related disease usually affects the parenchyma of the salivary gland via an autoimmune reaction. A Küttners’ tumor is a rare salivary gland disease related with IgG4+ lymphocytic infiltration and fibrosis. Herein, we report an adult male case of Küttner’s tumor of the submandibular gland and discuss its clinical features, diagnostic methods, and treatment algorithms in the light of the literature data.