Silah sesi nedeniyle akustik travma geçiren hastaların biyokimyasal ve hematolojik parametreleri
Murat Salihoglu1, Onuralp Kurt2, Aytug Altundag3, Melih Cayonu4
1Gata Haydarpaşa Eğitim Hasatanesi, Kulak Burun Boğaz A.b.d., İstanbul, Türkiye
2Erzincan Asker Hastanesi, Kulak Burun Boğaz Bölümü, Erzincan, Türkiye
3İstanbul Cerrahi Hastanesi, Kulak Burun Boğaz Bölümü, İstanbul, Türkiye
4Amasya Üniversitesi Eğitim Ve Araştırma Hastanesi, Kulak Burun Boğaz Bölümü, Amasya, Türkiye
Keywords: Acoustic trauma, folate, homocysteine, sensorineural hearing loss, vitamin B12.
Abstract
OBJECTIVE: In this study, we aimed to evaluate the biochemical and hematologic parameters of patients with acoustic trauma-induced hearing loss caused by gunshot noise.
METHODS: Fifty one male participants (23.1±3.4 years; range 21 to 36 years) were included in the study. The acoustic trauma group was constituted of 25 patients admitted with hearing loss after the firearm training. Whereas the healthy controls were selected randomly from the participants (n=26) without any complaint of hearing loss or tinnitus after the same firearm training. The biochemical and hematological parameters were compared between the study and control groups.
RESULTS: Serum folate and vitamin B12 levels were decreased in patients with acoustic trauma compared to healthy controls (p<0.001 and p=0.04, respectively). Homocysteine levels were significantly increased in patients with acoustic trauma than the control group (p<0.001). Activated partial thromboplastin time was significantly shorter in patients with acoustic trauma than healthy controls (p<0.001).
CONCLUSION: The changes in folate, vitamin B12, and homocysteine levels may contribute, in part at least, to the pathophysiological mechanism of acoustic trauma. Therefore, these parameters should be investigated in patients with acoustic trauma-induced hearing loss.